Audience targeting can be defined as the collection of consumer attributes expressed through a user's offline and online behavior, profile information or declared interest. This data is collected and sorted and then user is categorized into one or more audience segments and then being used for more precise online targeting. The ad placement targets the information in the users cookie vs. data provided by the website about its visitors.
The ad placement can be ran on a variety of different types of sites as it is targeting the user based off the information in the cookie .For example, if your business is selling running shoes and you target male runners under 35, once the cookie identifies a user as in your audience, that user will be targeted across different sites across the web. This is different from site targeting, where you would advertise across different running sites because you are targeting the site's audience.